Among biodegradable polymers poly(vinyl alcohol), (PVOH) is the most commercially water soluble plastic in use for a wide range of applications such as protective coatings, packaging industry and adhesives. Owing to extensive application of PVOH, many attempts have been accomplished to improve its functional properties as well as to expand the processing opportunity to the melt processing. In order to overcome some of its limited performances, engineering-designed PVOH nanocomposites with clay and organo-clay filler have been investigated. Recently a high amorphous polyvinyl alcohol (HAVOH) which can be easily melt processed has been patented and commercialized with the name G-Polymer. This new biodegradable vinyl alcohol polymer is particularly interesting due to its outstanding oxygen barrier properties. In this work, we report on the characterization of clay-G-Polymer nanocomposites obtained by melt processing of HAVOH with two commercial organoclays. In details Cloisite 15A and Closite 30B, obtained by modifying clay respectively with a quaternary ammonium salt of dimethyl dehydrogenated tallow and an alkyl ammonium salt of bis-(2-hydroxyethyl)methyl tallow, have been added to the polymer by melt compounding. Results show that the extent of polymer intercalation in the layered clay structure depends on the organic modifier. In fact the glass transition temperature increases only in the case of Cloisite 15A-based materials whereas the mechanical characterization shows that they are more brittle than the samples with Closite 30B. This is ascribed to a better intercalation of the polymer assisted by the presence of quaternary ammonium salt of dimethyl dehydrogenated tallow as confirmed by WAXD analysis. The presence of intercalated clay microparticles does not affect water barrier properties in comparison to pristine materials despite rheological measurement confirm that the clays affect the established network of H-bonding interactions within the polymer matrix.